Preclinical Stage

Drug discovery, redefined by computation.

Axia Discovery combines physics-based molecular simulation, generative AI, and multi-omics data to identify and validate novel drug candidates — faster, and with greater precision than conventional approaches.

10×
Faster hit identification
De Novo
Generative peptide design
High
Predictive accuracy
The Axia Platform

End-to-end computational drug discovery

From target to candidate, our integrated platform compresses timelines while elevating the quality of every decision.

Target Identification

Genomics · Proteomics

Multi-omics integration and network biology to uncover disease-relevant targets with high therapeutic confidence.

Structure-Based Design

Physics-Based · Selectivity

Designs and scores novel peptide candidates against validated targets with physics-based simulation — prioritizing binding and selectivity through a proprietary scoring edge, not brute-force library screening.

Generative Chemistry

GenAI · De Novo Design

Graph neural networks and diffusion models generate novel scaffolds optimized for selectivity, potency, and synthetic accessibility.

Molecular Dynamics

GROMACS · OpenMM

GPU-accelerated MD simulations reveal binding mechanisms and conformational dynamics invisible to static docking.

ADMET Prediction

PK/PD · Safety

Deep learning ADMET models trained on large-scale experimental data predict pharmacokinetic liabilities early in the campaign.

Lead Optimization

Active Learning · FEP

Bayesian optimization loops integrate experimental feedback in real time, guiding medicinal chemistry toward the ideal candidate.

Pipeline

Eight patent-pending programs

De novo-designed cyclic peptides across CNS, oncology, cardiometabolic, and renal indications. Nine U.S. provisional patent applications filed 2026.

Full pipeline →
Target ID
Design
Hit-to-Lead
Lead Opt.
Preclinical
CNS / Neuropsychiatry
AX-GRM1patent pending
Neurological disorders
mGluR1 (GRM1)
Preclinical
AX-HTR2C-ANTpatent pending
Depression / anxiety / CNS
5-HT2C receptor (HTR2C)
Preclinical
AX-HTR2C-AGOpatent pending
DEE / obesity
5-HT2C receptor (HTR2C)
Preclinical
Oncology · RLT
AX-GPRC5Dpatent pending
Multiple myeloma
GPRC5D
Preclinical
AX-GPR160patent pending
Solid tumors
GPR160
Preclinical
AX-KISS1Rpatent pending
Endometrial carcinoma
KISS1R (GPR54)
Preclinical
Cardiometabolic
AX-APLNRpatent pending
Heart failure / PAH / cardiometabolic
Apelin receptor (APLNR/APJ)
Preclinical
Renal
AX-CASRpatent pending
Secondary hyperparathyroidism (CKD-MBD)
Calcium-sensing receptor (CaSR/CASR)
Preclinical

All programs preclinical · Patent pending · PCT international filings anticipated · Pipeline subject to change

Scientific Foundation

Rigorous methodology, measurable outcomes

Our platform combines state-of-the-art computational methods with validated workflows to deliver reliable predictions.

10×
Faster hit identification
Compared to traditional HTS
De Novo
Generative peptide design
Designed, not library-screened
High
Predictive accuracy
Validated against experimental data
FEP+
Physics-based methods
Free energy perturbation & MD
Partner with Axia

Ready to accelerate your drug discovery program?

Whether you're seeking a computational co-development partner, licensing opportunities, or looking to advance a difficult target — let's talk.